L’International Society for Proton Dynamics in Cancer illustra i primi risultati degli studi clinici basati su terapie non invasive. Tutte le novità internazionali della ricerca scientifica translazionale che dal laboratorio vanno al letto del malato.

Al Simposio internazionale intervengono tra gli altri il Presidente dell’ISS Enrico Garaci, il Direttore del Reparto Farmaci antitumorali dell’ISS Stefano Fais, il Dr Stefano Vella Direttore del Dipartimento del Farmaco e ricercatori di tutto il mondo. Fra tutti il Dr Gatenby (H. Lee Moffit Cancer Center, Tampa, Fl, USA) ed il Prof Kusuzaki K (Università di Kioto, Giappone) che contribuiranno a fornire dati clinici sul nuovo approccio anti-tumorale.

Lunedì 27 settembre 2010 ore 09.00
Sede: Aula Pocchiari – Istituto Superiore di Sanità

SCIENTIFIC PROGRAMME

27th September

09:00-10:00 Opening and Welcome
- Prof. Enrico Garaci, President ISS.
- Dr. Stefano Vella, Director Dept. Therapeutic Research and Medicine Evaluation
- Dr. Stefano Fais, Director Antitumor Drugs Unit, ISPDC President

Session I. Cancer Metabolism and pH

Chair: Jacques Pouysségur, Pierre Sonveaux

10:00-10:30 J. Pouysségur
Novel Anticancer approaches by targeting hypoxia-regulated pHi-regulating systems

10:30-11:00 Angela Otto
Effect of extracellular pH on tumor cell growth and metabolism under limiting microenvironmental conditions

11:00-11:30 Coffee break

Session I. Cancer Metabolism and pH

11:30-13:00 Selected presentations

11:30-11:45 Hofmann P
High Intensity Exercise and Tumor Metabolism Lessons from the Lactate Shuttle Theory

11:45-12:00 Chiche J
Inhibition of the hypoxia-induced pHi-regulating system CAIX and CAXII compromises tumor progression in combination with ionizing radiation

12:00-12:15 Lagadic-Gossmann D
GSK3α is a new target for NHE1 in carcinogen-induced cell death

12:15-12:30 Sonveaux P
Lactic acid in tumors: metabolic fuel and signaling agent

12:30-12:45 Jen-Tsan Ashley Chi
The integrative frameworks for analysis of the influence of hypoxia and lactic acidosis in human cancers

12:45-13:00 Barbara Seliger
Changes in the expression of proteins involved in the metabolism of renal cell carcinoma and their use as potential targets for T cell-based immunotherapies

13:00-14:30 Lunch break

Session II. Proton dynamics and pH homeostasis

Chair: Angelo De Milito, Dominique Lagadic-Gossmann

14:30-15:00 M.G. Palmgren

15:00-15:30 C. Supuran
Carbonic Anhydrases IX and XII as antitumor targets

15:30-16:15 Swietach P
The role of transporters, buffers and enzymes in spatial pH regulation, studied in multi-cellular tumour models

16:15-16:45 Coffee break

Session II. Proton dynamics and pH homeostasis

16:45-18:00 Selected presentations

16:45-17:00 Parks SK
Investigating the role of hypoxia-inducible bicarbonate transporters in tumor cell pH regulation and survival

17:00-17:15 Counillon L
The Na+/H+ exchanger NHE-1, a crucial cellular integrator controlled by its membrane environment

17:15-17:30 Brisson L
Voltage-gated sodium channel activity promotes cysteine cathepsins-dependent invasiveness of breast cancer cells through the regulation of the sodium-proton exchanger NHE1

17:30-17:45 Hernandez A
Vacuo-lysosomal abnormal sterol accumulation induces cell death through inhibition of V-ATPase function. A study using yeast as a model system

17:45-18:00 De Milito A
Rationale for the use of proton pump inhibitors in antitumor therapies

18:00-19:00 ISPDC assembly
20:30 social dinner

28th September

Session III. Tumor acidity and malignancy

Chair: Stefano Fais, Robert A. Gatenby

09:00-09:30 R.A. Gatenby
Extracellular pH in cancer biology, from mathematical models to clinical trials

9:30-10:00 S. Reshkin
NHE1-dependent extracellular acidification is necessary for protease-dependent invadopodia ECM proteolysis and this is regulated by a phospho-ezrin signaling axis

10:00-10:30 Stock CM
Decorin and chondroitin-6 sulfate hinder melanoma cell migration and invasion by inducing cellular acidification

10:30-11:00 Coffee break

Session III. Tumor acidity and malignancy

11:00-11:30 Pedersen SF
NBCn1 and NHE1 expression and activity in ΔNErbB2 receptor-expressing MCF-7 breast cancer cells: Contributions to pHi regulation and chemotherapy resistance

11:30-12:00 Rauch C
On the role of the Universe’s dimensions in pH & Pgp mediated multidrug resistance in cancer

12:00-12:15 Lozupone F
Characterization of TM9SF4 a new protein associated with tumor cannibalism and pH alteration of metastatic melanoma

12:15-12:30 Pérez Sayáns M
Measurement of ATP6V1C1 expression in brush cytology samples as a diagnostic and prognostic marker in oral squamous cell carcinoma

12:30-12:45 Marino ML
Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

12:45-13:00 Hosogi S
Na+/H+ exchanger isoform 1 (NHE-1)-dependent proliferation of gastric cancer cells

13:00-14:30 Lunch break

Session IV. Translational research on proton transport in cancer

Chair: Stephan Reshkin, Salvador Harguindey

14:30-15:00 Kusuzaki K
Translational research of photodynamic therapy with acridine orange which targets acidic vesicles and environment of cancer cells

15:00-15:30 S. Harguindey
Towards a clinical protocol to treat cancer patients with the concerted use of proton transport inhibitors (PTIs)

15:30-16:00 S. Fais
Some results on the use of PPI as chemosensitizers in patients with melanoma and osteosarcoma

16:00-16:30 Coffee break

Session IV. Translational research on proton transport in cancer

16:30-16:45 Matsubara T
Acridine orange used for photodynamic therapy accumulates in malignant musculoskeletal tumors depending on extracellular pH: association with treatment outcome

16:45-17:00 Spugnini E
Proton pump inhibitors as anti vacuolar-ATPases drugs: preliminary findings in companion animals with spontaneous neoplasms

17:00-17:15 Clement MV
The pH regulator, NHE-1: a possible new target for more efficient and specific anticancer treatment

17:15-17:30 To be defined

17:30-18:00 Round table, final discussion and conference closing

Info: Ufficio Stampa ISS